Journal: bioRxiv

Article Title: Beta Waves in Action: Context-Dependent Modulations of Subthalamo-Cortical Synchronization during Rapid Reversals of Movement Direction

doi: 10.1101/2024.08.19.608624

Figure Lengend Snippet: (a, b) 3D source-reconstruction in MNI space. N = 20. White crosses mark the cortical ROIs selected for further analysis based on the strongest relative change in power ( a ) and the strongest absolute change in coherence ( b ). (c) All patients’ DBS electrodes, localized with Lead-DBS.

Article Snippet: The positions of DBS electrodes were localized with the MATLAB toolbox Lead-DBS ( ) using the patients’ pre-operative T1-and T2-weighted MRIs (Magnetom Trio MRI scanner, Siemens, Erlangen, Germany) and postoperative CT scans ( ).

Techniques:

Journal: NPJ Parkinson's Disease

Article Title: Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease

doi: 10.1038/s41531-024-00668-4

Figure Lengend Snippet: a DBS lead construction via LeadDBS toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.

Article Snippet: The lead positions in PD patients were confirmed with a MATLAB toolbox-LeadDBS (v2.1.8, https://www.lead-dbs.org ) via fusion of preoperative magnetic resonance imaging (MRI) and postoperative computed tomography (CT) , the results showed that the leads were accurately implanted into the STN (Fig. ).

Techniques: Expressing, Standard Deviation

Journal: Data in Brief

Article Title: A structural group-connectome in standard stereotactic (MNI) space

doi: 10.1016/j.dib.2015.08.035

Figure Lengend Snippet: Example application of the group connectome. Deep brain stimulation electrodes of a patient suffering from Parkinson's Disease were reconstructed based on post-operative structural MR imaging. The volume of tissue that was stimulated (VAT) was estimated based on a model by Mädler and Coenen and the actual stimulation settings of the patient's implanted pulse generator. Fiber tracts that traversed through the VAT were selected from the group connectome. Areas that were connected to the VAT by selected fiber tracts were selected from the automated anatomic labeling (AAL) atlas and visualized. In addition to AAL regions, subcortical nuclei from the ATAG-atlas are visualized: striatum (red), external part of the pallidum (blue), internal part (cyan), subthalamic nucleus (orange), red nucleus (green), substantia nigra (yellow). Analyzes and visualization were performed directly within MNI space using LEAD-DBS software (Horn, 2015; www.lead-dbs.org ).

Article Snippet: It can be directly used to perform analyzes in LEAD DBS ( www.lead-dbs.org ; Matlab; [ ]) and TrackVis software. shows 3% of fibers stored within the dataset.

Techniques: Imaging, Labeling, Software

Journal: Data in Brief

Article Title: A structural group-connectome in standard stereotactic (MNI) space

doi: 10.1016/j.dib.2015.08.035

Figure Lengend Snippet:

Article Snippet: It can be directly used to perform analyzes in LEAD DBS ( www.lead-dbs.org ; Matlab; [ ]) and TrackVis software. shows 3% of fibers stored within the dataset.

Techniques: Diffusion-based Assay